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Physical & Safety Data

Physical Properties

Molecular weight:311.9; Physical form:Colourless liquid. Density:1.076 (20 °C); Flash point:129 °C (EEC A9); Vapour pressure:0.133 mPa (20 °C); Henry constant:8.1× 10-4 Pa m3 mol-1; Partition coefficient(n-octanol and water):logP = 4.08 (shake flask); Solubility:In water 50 mg/l (20 °C). Very soluble in benzene, hexane, methanol and dichloromethane.; Stability:Relatively stable to hydrolysis; DT50 (calc.) (20 °C) >200 d (pH 1-9), 14 d (pH 13).

Toxicology

Oral:Acute oral LD50 for rats 6099 mg/ kg. Percutaneous:Acute percutaneous LD50 for rats >3100 mg/kg. Moderate irritant to skin; non-irritant to eyes (rabbits). Inhalation: LC50 (4 h) for rats >2.8 mg/l air. Phytotoxicity:Applied alone, pretilachlor will cause injury to direct-seeded rice.

Environmental Profile

Ecotoxicology: 
Algae: EC50 for Selenastrum capricornutum 0.002 mg/l.Bees: LD50 (contact) 93µg/bee.Birds:Non-toxic to birds; LD50 for Japanese quail >10 000 mg/kg. LC50 for Japanese quail >1000 ppm.Daphnia: LC50 13 mg/l.Fish: LC50 (96 h) for rainbow trout 0.9, catfish 2.7, crucian carp 2.3 mg/l. 

Environmental fate: 
Animals:Substitution of the chlorine atom for glutathione to form a conjugate. Cleavage of the ether bond to yield an ethyl alcohol derivative. Both metabolites are susceptible to further degradation.Soil:Applied to paddy water, pretilachlor disappeared from the water by adsorption to the soil, where it is rapidly degraded under practical conditions, median DT50 (lab.) 30 d. Due to strong soil adsorption, unlikely to leach.Plant:Substitution of the chlorine atom to form a conjugate. Cleavage of the ether bond to yield an ethyl alcohol derivative. Hydrolytic and reductive removal of the chlorine atom. WATER SOLUBILITY: 50 mg/l at 20° C

Transport Information

Hazard Class:III(Slightly hazardous)